Endocrine Abstracts

Introduction: Parabens are a group of chemicals used as preservatives in the food, cosmetic and pharmaceutical industries. They are known to possess estrogenic effects, and therefore have been classified as endocrine disruptors. In addition to the classical endocrine organs, other tissues have endocrine activity, including adipose tissue. Several chemicals are known to cause obesogenic effects, and parabens are currently being studied in this context. The aim of this study was...

Context: The cyclical effects of hormones during the menstrual cycle (MC) are responsible for driving ovulation. The information about roles of adipokines within the scope of MC are not definite. Leptin plays a role in sexual function and regulating the onset of puberty. Thin girls often fail to ovulate or release an egg from an ovary during menstruation cycles. Leptin also acts on specific receptors in the hypothalamus to inhibit appetite. Levels of leptin are increased in wo...

Background: Skin autofluorescence (SAF), measured with the AGE-reader, predicts cardiovascular disease (CVD) and type 2 diabetes (T2D). Thyroid hormone levels (TH) may affect this association. In the present study, we examined whether TH predict 4-years risk of T2D, CVD and mortality in the general population independently of SAF.Methods: We included 28245 participants (age 44±12 years, BMI 25.9±4.3 kg/m2) of the Dutch Lifelines Coho...

Background: The metabolic syndrome (MetS) is a combination of unfavourable health factors including visceral obesity, dyslipidaemia, hypertension and impaired fasting glucose. It is also strongly associated with increased risk of cardiovascular disease (CVD) and type 2 diabetes. We assessed which factors contribute to the prevalence of MetS in people within different weight and age categories.Methods: 64 046 western European participants aged 18–80 ...

Introduction: The Thr92Ala polymorphism of deiodinase 2 (DIO2) is associated with increased expression in the brain of genes associated with oxidative stress, and may predict favourable response to combination thyroxine (L-T4) plus triiodothyronine (T3) therapy. We examined whether the Thr92Ala polymorphism (rs225014) was associated with differences in thyroid hormone parameters, health-related quality of life (HR-QOL) and cognitive functio...

The determination of steroid hormones and subsequent interpretation of results is accompanied by a range of difficulties. The amount of information that current technology can provide on the circulating concentrations of more than a hundred various steroid compounds can lead to problems with interpretation. The aim of this study is to help provide orientation in this maze of data on steroid hormones. First, we focus on specific aspects arising from the pre-analytical phase of ...